| First Authors |
Björn Drobot
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| Authors |
Björn Drobot, Juan M Iglesias-Artola, Kristian Le Vay, Viktoria Mayr, Mrityunjoy Kar, Moritz Kreysing, Hannes Mutschler, T-Y Dora Tang
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| Corresponding Authors |
Moritz Kreysing, Hannes Mutschler, T-Y Dora Tang
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| Last Authors |
T-Y Dora Tang
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| Journal Name |
Nature communications (Nat Commun) |
| Volume |
9 |
| Issue |
1 |
| Article Number |
3643 |
| Open Access |
true |
| Print Publication Date |
2018-09-07 |
| Online Publication Date |
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| Abstract |
Phase separation of mixtures of oppositely charged polymers provides a simple and direct route to compartmentalisation via complex coacervation, which may have been important for driving primitive reactions as part of the RNA world hypothesis. However, to date, RNA catalysis has not been reconciled with coacervation. Here we demonstrate that RNA catalysis is viable within coacervate microdroplets and further show that these membrane-free droplets can selectively retain longer length RNAs while permitting transfer of lower molecular weight oligonucleotides. |
| PDF |
Drobot_2018_7196.pdf
(1.8 MB)
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| Cover Image |
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| Supplementary Data |
Supplementary
Data
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| Affiliated With |
Kreysing, Postdoc first author, Postdocs, Tang, Postdoc first male
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| Selected By |
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| Acknowledged Services |
Scientific Computing Facility, Light Microscopy Facility
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| Publication Status |
Published |
| Edoc Link |
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| Sfx Link |
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| DOI |
10.1038/s41467-018-06072-w |
| PubMed ID |
30194374 |
| WebOfScience Link |
WOS:000444014100018 |
| Alternative Full Text URL |
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| Display Publisher Download Only |
false |
| Visible On MPI-CBG Website |
true |
| PDF Downloadable |
true |
| Created By |
joegema |
| Added Date |
2018-08-15 |
| Last Edited By |
herbst |
| Last Edited Date |
2021-05-27 18:01:52.427 |
| Library ID |
7196 |
| Document ID |
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| Entry Complete |
true |
| eDoc Compliant |
true |
| Include in Edoc Report |
true |
| In Pure |
false |
| Ready for eDoc Export |
false |
| Author Affiliations Complete |
false |
| Project Name |
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| Project URL |
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| Grant ID |
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| Funding Programme |
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| Funding Organisation |
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