First Authors | Malte Lehmann |
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Authors | Malte Lehmann, Elisabeth Knust, Sarita Hebbar |
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Last Authors | Sarita Hebbar |
Journal Name | Methods in molecular biology (Clifton, N.J.) (Methods Mol Biol) |
Volume | 1834 |
Issue | |
Page Range | 221-249 |
Open Access | false |
Print Publication Date | 2019-01-01 |
Online Publication Date | 2018-10-16 |
Abstract | Retinitis pigmentosa (RP) is a complex inherited disease. It is associated with mutations in a wide variety of genes with many different functions. These mutations impact the integrity of rod photoreceptors and ultimately result in the progressive degeneration of rods and cone photoreceptors in the retina, leading to complete blindness. A hallmark of this disease is the variable degree to which symptoms are manifest in patients. This is indicative of the influence of the environment, and/or of the distinct genetic makeup of the individual.The fruit fly, Drosophila melanogaster, has effectively proven to be a great model system to better understand interconnected genetic networks. UnravelingĀ genetic interactions and thereby different cellular processes is relatively easy because more than a century of research on flies has enabled the creation of sophisticated genetic tools to perturb gene function. A remarkable conservation of disease genes across evolution and the similarity of the general organization of the fly and vertebrate photoreceptor cell had prompted research on fly retinal degeneration. To date six fly modelsĀ for RP, including RP4, RP11, RP12, RP14, RP25, and RP26, have been established, and have provided useful information on RP disease biology. In this chapter, an outline of approaches and experimental specifications are described to enable utilizing or developing new fly models of RP. |
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Affiliated With | Knust, Postdocs |
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Acknowledged Services | Media Technology and Outreach |
Publication Status | Published |
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DOI | 10.1007/978-1-4939-8669-9_16 |
PubMed ID | 30324448 |
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Display Publisher Download Only | false |
Visible On MPI-CBG Website | true |
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Created By | verhegge |
Added Date | 2018-11-22 |
Last Edited By | verhegge |
Last Edited Date | 2018-12-05 13:25:36.688 |
Library ID | 7271 |
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