Adaptive particle representation of fluorescence microscopy images.

First Authors Bevan Cheeseman
Authors Bevan Cheeseman, Ulrik Günther, Krzysztof Gonciarz, Mateusz Susik, Ivo F. Sbalzarini
Corresponding Authors Ivo F. Sbalzarini
Last Authors Ivo F. Sbalzarini
Journal Name Nature communications (Nat Commun)
Volume 9
Issue 1
Article Number 5160
Open Access true
Print Publication Date 2018-12-04
Online Publication Date
Abstract Modern microscopes create a data deluge with gigabytes of data generated each second, and terabytes per day. Storing and processing this data is a severe bottleneck, not fully alleviated by data compression. We argue that this is because images are processed as grids of pixels. To address this, we propose a content-adaptive representation of fluorescence microscopy images, the Adaptive Particle Representation (APR). The APR replaces pixels with particles positioned according to image content. The APR overcomes storage bottlenecks, as data compression does, but additionally overcomes memory and processing bottlenecks. Using noisy 3D images, we show that the APR adaptively represents the content of an image while maintaining image quality and that it enables orders of magnitude benefits across a range of image processing tasks. The APR provides a simple and efficient content-aware representation of fluosrescence microscopy images.
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Affiliated With Predoc first male, CSBD, Predoc first author, Sbalzarini
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DOI 10.1038/s41467-018-07390-9
PubMed ID 30514837
WebOfScience Link WOS:000452042500011
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Created By sbalzari
Added Date 2018-12-04
Last Edited By herbst
Last Edited Date 2021-05-27 17:40:57.965
Library ID 7292
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