First Authors | João P L Castro, Michelle N Yancoskie |
---|---|
Authors | João P L Castro, Michelle N Yancoskie, Marta Marchini, Stefanie Belohlavy, Layla Hiramatsu, Marek Kučka, William H Beluch, Ronald Naumann, Isabella Skuplik, John Cobb, Nick H Barton, Campbell Rolian, Yingguang Frank Chan |
Corresponding Authors | Campbell Rolian, Yingguang Frank Chan |
Last Authors | Yingguang Frank Chan |
Journal Name | eLife (Elife) |
Volume | 8 |
Issue | |
Article Number | e42014 |
Open Access | true |
Print Publication Date | 2019-06-06 |
Online Publication Date | |
Abstract | Evolutionary studies are often limited by missing data that are critical to understanding the history of selection. Selection experiments, which reproduce rapid evolution under controlled conditions, are excellent tools to study how genomes evolve under selection. Here we present a genomic dissection of the Longshanks selection experiment, in which mice were selectively bred over 20 generations for longer tibiae relative to body mass, resulting in 13% longer tibiae in two replicates. We synthesized evolutionary theory, genome sequences and molecular genetics to understand the selection response and found that it involved both polygenic adaptation and discrete loci of major effect, with the strongest loci tending to be selected in parallel between replicates. We show that selection may favor de-repression of bone growth through inactivating two limb enhancers of an inhibitor, Nkx3-2. Our integrative genomic analyses thus show that it is possible to connect individual base-pair changes to the overall selection response. |
Cover Image | |
Affiliated With | Transgenic Core Facility |
Selected By | Transgenic Core Facility |
Acknowledged Services | Biomedical Services |
Publication Status | Published |
Edoc Link | |
Sfx Link | |
DOI | 10.7554/eLife.42014 |
PubMed ID | 31169497 |
WebOfScience Link | WOS:000473588700001 |
Alternative Full Text URL | |
Display Publisher Download Only | false |
Visible On MPI-CBG Website | true |
PDF Downloadable | true |
Created By | naumann |
Added Date | 2019-06-08 |
Last Edited By | thuem |
Last Edited Date | 2020-05-11 19:28:09.538 |
Library ID | 7408 |
Document ID | |
Entry Complete | true |
eDoc Compliant | true |
Include in Edoc Report | true |
In Pure | |
Ready for eDoc Export | |
Author Affiliations Complete | false |
Project Name | |
Project URL | |
Grant ID | |
Funding Programme | |
Funding Organisation |