First Authors | Kassiani Skouloudaki |
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Authors | Kassiani Skouloudaki, Ioannis Christodoulou, Dilan Khalili, Vasilios Tsarouhas, Christos Samakovlis, Pavel Tomancak, Elisabeth Knust, Dimitrios Papadopoulos |
Corresponding Authors | Kassiani Skouloudaki, Elisabeth Knust, Dimitrios Papadopoulos |
Last Authors | Dimitrios Papadopoulos |
Journal Name | Journal of cell biology, The (J Cell Biol) |
Volume | 218 |
Issue | 8 |
Page Range | 2762-2781 |
Open Access | false |
Print Publication Date | 2019-08-05 |
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Abstract | Epithelial organ size and shape depend on cell shape changes, cell-matrix communication, and apical membrane growth. The Drosophila melanogaster embryonic tracheal network is an excellent model to study these processes. Here, we show that the transcriptional coactivator of the Hippo pathway, Yorkie (YAP/TAZ in vertebrates), plays distinct roles in the developing Drosophila airways. Yorkie exerts a cytoplasmic function by binding Drosophila Twinstar, the orthologue of the vertebrate actin-severing protein Cofilin, to regulate F-actin levels and apical cell membrane size, which are required for proper tracheal tube elongation. Second, Yorkie controls water tightness of tracheal tubes by transcriptional regulation of the δ-aminolevulinate synthase gene (Alas). We conclude that Yorkie has a dual role in tracheal development to ensure proper tracheal growth and functionality. |
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Affiliated With | Knust, Postdoc first author, Postdocs, Tomancak, Postdoc first female |
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Publication Status | Published |
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DOI | 10.1083/jcb.201809121 |
PubMed ID | 31315941 |
WebOfScience Link | WOS:000478788200022 |
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Display Publisher Download Only | false |
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Created By | thuem |
Added Date | 2019-07-30 |
Last Edited By | herbst |
Last Edited Date | 2021-04-29 16:52:19.837 |
Library ID | 7442 |
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Entry Complete | true |
eDoc Compliant | true |
Include in Edoc Report | true |
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Ready for eDoc Export | false |
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