First Authors | Simon Alberti |
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Authors | Simon Alberti, Dirk Dormann |
Corresponding Authors | |
Last Authors | Dirk Dormann |
Journal Name | Annual review of genetics (Annu Rev Genet) |
Volume | 53 |
Issue | |
Page Range | 171-194 |
Open Access | false |
Print Publication Date | 2019-12-03 |
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Abstract | We have made rapid progress in recent years in identifying the genetic causes of many human diseases. However, despite this recent progress, our mechanistic understanding of these diseases is often incomplete. This is a problem because it limits our ability to develop effective disease treatments. To overcome this limitation, we need new concepts to describe and comprehend the complex mechanisms underlying human diseases. Condensate formation by phase separation emerges as a new principle to explain the organization of living cells. In this review, we present emerging evidence that aberrant forms of condensates are associated with many human diseases, including cancer, neurodegeneration, and infectious diseases. We examine disease mechanisms driven by aberrant condensates, and we point out opportunities for therapeutic interventions. We conclude that phase separation provides a useful new framework to understand and fight some of the most severe human diseases. |
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Affiliated With | Alberti |
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Publication Status | Published |
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DOI | 10.1146/annurev-genet-112618-043527 |
PubMed ID | 31430179 |
WebOfScience Link | WOS:000501596100008 |
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Display Publisher Download Only | false |
Visible On MPI-CBG Website | true |
PDF Downloadable | true |
Created By | thuem |
Added Date | 2019-08-27 |
Last Edited By | thuem |
Last Edited Date | 2020-01-06 12:18:53.78 |
Library ID | 7482 |
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Entry Complete | true |
eDoc Compliant | true |
Include in Edoc Report | true |
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Author Affiliations Complete | false |
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