| First Authors | Yuting Wang |
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| Authors | Yuting Wang, Sebastian Hinz, Ortrud Uckermann, Pia Hönscheid, Witigo von Schönfels, Greta Burmeister, Alexander Hendricks, Jacobo Miranda Ackerman, Gustavo Baretton, Jochen Hampe, Mario Brosch, Clemens Schafmayer, Andrej Shevchenko, Sebastian Zeissig |
| Corresponding Authors | Andrej Shevchenko, Sebastian Zeissig |
| Last Authors | Sebastian Zeissig |
| Journal Name | Biochimica et biophysica acta. Molecular and cell biology of lipids (Biochim Biophys Acta Mol Cell Biol Lipids) |
| Volume | 1865 |
| Issue | 3 |
| Article Number | 158579 |
| Open Access | false |
| Print Publication Date | 2020-01-01 |
| Online Publication Date | |
| Abstract | Solid tumors are characterized by global metabolic alterations which contribute to their growth and progression. Altered gene expression profiles and plasma lipid composition suggested a role for metabolic reprogramming in colorectal cancer (CRC) development. However, a conclusive picture of CRC-associated lipidome alterations in the tumor tissue has not emerged. Here, we determined molar abundances of 342 species from 20 lipid classes in matched biopsies of CRC and adjacent normal mucosa. We demonstrate that in contrast to previous reports, CRC shows a largely preserved lipidome composition that resembles that of normal colonic mucosa. Important exceptions include increased levels of lyso-phosphatidylinositols in CRC and reduced abundance of ether phospholipids in advanced stages of CRC. As such, our observations challenge the concept of widespread alterations in lipid metabolism in CRC and rather suggest changes in the cellular lipid profile that are limited to selected lipids involved in signaling and the scavenging of reactive oxygen species. |
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| Affiliated With | Shevchenko |
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| Publication Status | Published |
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| DOI | 10.1016/j.bbalip.2019.158579 |
| PubMed ID | 31794862 |
| WebOfScience Link | WOS:000509816600005 |
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| Display Publisher Download Only | false |
| Visible On MPI-CBG Website | true |
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| Created By | thuem |
| Added Date | 2020-01-08 |
| Last Edited By | thuem |
| Last Edited Date | 2021-12-29 11:40:13.863 |
| Library ID | 7575 |
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| Entry Complete | true |
| eDoc Compliant | true |
| Include in Edoc Report | true |
| In Pure | true |
| Ready for eDoc Export | false |
| Author Affiliations Complete | false |
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