| First Authors | Lydie Flasse |
|---|---|
| Authors | Lydie Flasse, Siham Yennek, Cédric Cortijo, Irene Seijo Barandiaran, Marine R-C Kraus, Anne Grapin-Botton |
| Corresponding Authors | Lydie Flasse, Anne Grapin-Botton |
| Last Authors | Anne Grapin-Botton |
| Journal Name | Cell reports (Cell Rep) |
| Volume | 31 |
| Issue | 8 |
| Article Number | 107677 |
| Open Access | true |
| Print Publication Date | 2020-05-26 |
| Online Publication Date | |
| Abstract | Cell polarity is essential for the architecture and function of numerous epithelial tissues. Here, we show that apical restriction of planar cell polarity (PCP) components is necessary for the maintenance of epithelial integrity. Using the mammalian pancreas as a model, we find that components of the core PCP pathway, such as the transmembrane protein Van Gogh-like (VANGL), become apically restricted over a period of several days. Expansion of VANGL localization to the basolateral membranes of progenitors leads to their death and disruption of the epithelial integrity. VANGL basolateral expansion does not affect apico-basal polarity but acts in the cells where Vangl is mislocalized by reducing Dishevelled and its downstream target ROCK. This reduction in ROCK activity culminates in progenitor cell egression, death, and eventually pancreatic hypoplasia. Thus, precise spatiotemporal modulation of VANGL-dependent PCP signaling is crucial for proper pancreatic morphogenesis. |
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| Affiliated With | Grapin-Botton, Postdoc first author, Postdoc first female, Postdocs |
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| Publication Status | Published |
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| DOI | 10.1016/j.celrep.2020.107677 |
| PubMed ID | 32460029 |
| WebOfScience Link | WOS:000538167600007 |
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| Display Publisher Download Only | false |
| Visible On MPI-CBG Website | true |
| PDF Downloadable | true |
| Created By | thuem |
| Added Date | 2020-05-29 |
| Last Edited By | herbst |
| Last Edited Date | 2021-06-21 17:07:01.963 |
| Library ID | 7679 |
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| Entry Complete | true |
| eDoc Compliant | true |
| Include in Edoc Report | true |
| In Pure | true |
| Ready for eDoc Export | false |
| Author Affiliations Complete | false |
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