| First Authors | Michael Heide |
|---|---|
| Authors | Michael Heide, Christiane Haffner, Ayako Y Murayama, Yoko Kurotaki, Haruka Shinohara, Hideyuki Okano, Erika Sasaki, Wieland Huttner |
| Corresponding Authors | Michael Heide, Wieland Huttner |
| Last Authors | Wieland Huttner |
| Journal Name | Science (New York, N.Y.) (Science) |
| Volume | 369 |
| Issue | 6503 |
| Page Range | 546-550 |
| Open Access | false |
| Print Publication Date | 2020-07-31 |
| Online Publication Date | 2020-08-18 |
| Abstract | The neocortex has expanded during mammalian evolution. Overexpression studies in developing mouse and ferret neocortex have implicated the human-specific gene ARHGAP11B in neocortical expansion, but the relevance for primate evolution has been unclear. Here, we provide functional evidence that ARHGAP11B causes expansion of the primate neocortex. ARHGAP11B expressed in fetal neocortex of the common marmoset under control of the gene's own (human) promoter increased the numbers of basal radial glia progenitors in the marmoset outer subventricular zone, increased the numbers of upper-layer neurons, enlarged the neocortex, and induced its folding. Thus, the human-specific ARHGAP11B drives changes in development in the nonhuman primate marmoset that reflect the changes in evolution that characterize human neocortical development. |
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| Affiliated With | Huttner, Postdoc first author, Postdoc first male, Postdocs |
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| Acknowledged Services | Media Technology and Outreach, Scientific Computing Facility, Light Microscopy Facility |
| Publication Status | Published |
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| DOI | 10.1126/science.abb2401 |
| PubMed ID | 32554627 |
| WebOfScience Link | WOS:000556568100041 |
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| Display Publisher Download Only | false |
| Visible On MPI-CBG Website | true |
| PDF Downloadable | true |
| Created By | thuem |
| Added Date | 2020-06-19 |
| Last Edited By | herbst |
| Last Edited Date | 2021-06-21 17:24:50.96 |
| Library ID | 7693 |
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| Entry Complete | true |
| eDoc Compliant | true |
| Include in Edoc Report | true |
| In Pure | true |
| Ready for eDoc Export | false |
| Author Affiliations Complete | false |
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