| First Authors |
Jun Hoe Lee
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| Authors |
Jun Hoe Lee, Michael Hiller
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| Corresponding Authors |
Michael Hiller
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| Last Authors |
Michael Hiller
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| Book Volume Title |
Evolutionary Biology: Self/Nonself Evolution, Species and Complex Traits Evolution, Methods and Concepts |
| Series Title |
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| Chapter Number |
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| Publisher |
Springer International Publishing |
| Book Editors |
Pierre Pontarotti
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| ISBN |
978-3-319-61568-4 |
| First Page |
297 |
| Last Page |
312 |
| Open Access |
false |
| Print Publication Date |
2017-08-08 |
| Online Publication Date |
2017-08-08 |
| Abstract |
Convergent evolution can occur at both the phenotypic and molecular
level. Of particular interest are cases of convergent molecular changes that underlie
convergent phenotypic changes, as they highlight the genomic differences that
underlie phenotypic adaptations and can inform us on why evolution has repeatedly
chosen the same solution in lineages that have evolved independently. Many
approaches to identify convergent molecular evolution have focused on candidate
genes with known functions as well as lineages with known convergent pheno-
types. The growing amount of genomic sequence data makes it now possible to
systematically detect molecular convergence genome-wide. Here, we highlight the
advantages and drawbacks of using genomic screens to identify molecular con-
vergence. We present our method to detect convergent substitutions between any
pair of lineages in a genome-wide manner, ways of enriching for convergence that
are more likely to affect protein function, and present novel cases of convergence in
echolocating mammals. Our results suggest that genomic screens have the potential
to generate new hypotheses of associations between molecular convergence and
phenotypic convergence. Together with experimental assays to test for functional
convergence, this will contribute to revealing the genomic changes that underlie
convergent phenotypic changes. |
| PDF |
Lee_2017_7000.pdf
(666.4 kB)
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| Affiliated With |
Hiller, Predoc first author
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| Selected By |
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| Publication Status |
Published |
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| DOI |
10.1007/978-3-319-61569-1_16 |
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| Display Publisher Download Only |
false |
| Visible On MPI-CBG Website |
true |
| PDF Downloadable |
true |
| Created By |
thuem |
| Added Date |
2017-12-13 |
| Last Edited By |
thuem |
| Last Edited Date |
2018-12-06 10:22:31.027 |
| Library ID |
7000 |
| Document ID |
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| Entry Complete |
true |
| eDoc Compliant |
true |
| Include in Edoc Report |
true |
| In Pure |
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| Ready for eDoc Export |
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| Author Affiliations Complete |
false |
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