Genome-Wide Screens for Molecular Convergent Evolution in Mammals

First Authors Jun Hoe Lee
Authors Jun Hoe Lee, Michael Hiller
Corresponding Authors Michael Hiller
Last Authors Michael Hiller
Book Volume Title Evolutionary Biology: Self/Nonself Evolution, Species and Complex Traits Evolution, Methods and Concepts
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Publisher Springer International Publishing
Book Editors Pierre Pontarotti
ISBN 978-3-319-61568-4
First Page 297
Last Page 312
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Print Publication Date 2017-08-08
Online Publication Date 2017-08-08
Abstract Convergent evolution can occur at both the phenotypic and molecular level. Of particular interest are cases of convergent molecular changes that underlie convergent phenotypic changes, as they highlight the genomic differences that underlie phenotypic adaptations and can inform us on why evolution has repeatedly chosen the same solution in lineages that have evolved independently. Many approaches to identify convergent molecular evolution have focused on candidate genes with known functions as well as lineages with known convergent pheno- types. The growing amount of genomic sequence data makes it now possible to systematically detect molecular convergence genome-wide. Here, we highlight the advantages and drawbacks of using genomic screens to identify molecular con- vergence. We present our method to detect convergent substitutions between any pair of lineages in a genome-wide manner, ways of enriching for convergence that are more likely to affect protein function, and present novel cases of convergence in echolocating mammals. Our results suggest that genomic screens have the potential to generate new hypotheses of associations between molecular convergence and phenotypic convergence. Together with experimental assays to test for functional convergence, this will contribute to revealing the genomic changes that underlie convergent phenotypic changes.
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DOI 10.1007/978-3-319-61569-1_16
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Created By thuem
Added Date 2017-12-13
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Last Edited Date 2018-12-06 10:22:31.027
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