Protein tyrosine sulfation.

First Authors Denis Corbeil
Authors Denis Corbeil, Wieland B. Huttner
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Last Authors Wieland B. Huttner
Book Volume Title Encyclopedia of Biological Chemistry : Vol. 3 (3rd ed.)
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Publisher Elsevier
Book Editors Joseph Jez
ISBN 978-0-12-822040-5
First Page 192
Last Page 205
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Print Publication Date 2021-08-02
Online Publication Date 2021-08-02
Abstract Protein tyrosine O-sulfation is a posttranslational modification that takes place in the trans-Golgi network and occurs for a wide spectrum of transmembrane and secretory proteins found in all animals and in the plant kingdom. The sulfate transfer reaction to tyrosine residues is catalyzed by one of two tyrosylprotein sulfotransferases (EC which use the universal sulfate donor 3′-phosphoadenosine 5′-phosphosulfate. Protein tyrosine O-sulfation promotes extracellular protein–protein interactions occurring in various biological processes, ranging from receptor binding of regulated peptides to the interaction of viral envelope proteins with cell surface proteins. An overview of our knowledge of protein tyrosine sulfation is presented.
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DOI 10.1016/B978-0-12-809633-8.21571-9
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Created By thuem
Added Date 2021-07-08
Last Edited By herbst
Last Edited Date 2022-03-03 17:30:21.674
Library ID 8108
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