First Authors | Denis Corbeil |
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Authors | Denis Corbeil, Wieland B. Huttner |
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Last Authors | Wieland B. Huttner |
Book Volume Title | Encyclopedia of Biological Chemistry : Vol. 3 (3rd ed.) |
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Publisher | Elsevier |
Book Editors | Joseph Jez |
ISBN | 978-0-12-822040-5 |
First Page | 192 |
Last Page | 205 |
Open Access | false |
Print Publication Date | 2021-08-02 |
Online Publication Date | 2021-08-02 |
Abstract | Protein tyrosine O-sulfation is a posttranslational modification that takes place in the trans-Golgi network and occurs for a wide spectrum of transmembrane and secretory proteins found in all animals and in the plant kingdom. The sulfate transfer reaction to tyrosine residues is catalyzed by one of two tyrosylprotein sulfotransferases (EC 2.8.2.20) which use the universal sulfate donor 3′-phosphoadenosine 5′-phosphosulfate. Protein tyrosine O-sulfation promotes extracellular protein–protein interactions occurring in various biological processes, ranging from receptor binding of regulated peptides to the interaction of viral envelope proteins with cell surface proteins. An overview of our knowledge of protein tyrosine sulfation is presented. |
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Affiliated With | Huttner |
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Publication Status | Submitted |
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DOI | 10.1016/B978-0-12-809633-8.21571-9 |
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Alternative Full Text URL | https://www.elsevier.com/books/encyclopedia-of-biological-chemistry/jez/978-0-12-819460-7 |
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Created By | thuem |
Added Date | 2021-07-08 |
Last Edited By | herbst |
Last Edited Date | 2022-03-03 17:30:21.674 |
Library ID | 8108 |
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