| First Authors |
Virag Sharma
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| Authors |
Virag Sharma, Nikolai Hecker, Juliana G. Roscito, Leo Foerster, Björn Langer, Michael Hiller
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| Corresponding Authors |
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| Last Authors |
Michael Hiller
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| Journal Name |
Nature communications (Nat Commun) |
| Volume |
9 |
| Issue |
1 |
| Article Number |
1215 |
| Open Access |
true |
| Print Publication Date |
2018-03-23 |
| Online Publication Date |
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| Abstract |
Identifying the genomic changes that underlie phenotypic adaptations is a key challenge in evolutionary biology and genomics. Loss of protein-coding genes is one type of genomic change with the potential to affect phenotypic evolution. Here, we develop a genomics approach to accurately detect gene losses and investigate their importance for adaptive evolution in mammals. We discover a number of gene losses that likely contributed to morphological, physiological, and metabolic adaptations in aquatic and flying mammals. These gene losses shed light on possible molecular and cellular mechanisms that underlie these adaptive phenotypes. In addition, we show that gene loss events that occur as a consequence of relaxed selection following adaptation provide novel insights into species' biology. Our results suggest that gene loss is an evolutionary mechanism for adaptation that may be more widespread than previously anticipated. Hence, investigating gene losses has great potential to reveal the genomic basis underlying macroevolutionary changes. |
| PDF |
Sharma_2018_7077.pdf
(1.5 MB)
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| Cover Image |
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| Affiliated With |
CSBD, Hiller, Postdoc first author, Postdoc first male
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| Selected By |
Hiller
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| Acknowledged Services |
Media Technology and Outreach, Computer Department
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| Publication Status |
Published |
| Edoc Link |
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| Sfx Link |
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| DOI |
10.1038/s41467-018-03667-1 |
| PubMed ID |
29572503 |
| WebOfScience Link |
WOS:000428165400014 |
| Alternative Full Text URL |
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| Display Publisher Download Only |
false |
| Visible On MPI-CBG Website |
true |
| PDF Downloadable |
true |
| Created By |
hiller |
| Added Date |
2018-03-06 |
| Last Edited By |
herbst |
| Last Edited Date |
2021-05-27 18:08:42.411 |
| Library ID |
7077 |
| Document ID |
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| Entry Complete |
true |
| eDoc Compliant |
true |
| Include in Edoc Report |
true |
| In Pure |
false |
| Ready for eDoc Export |
false |
| Author Affiliations Complete |
false |
| Project Name |
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| Project URL |
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| Grant ID |
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| Funding Programme |
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| Funding Organisation |
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