| First Authors | Michael Heide |
|---|---|
| Authors | Michael Heide, Wieland B. Huttner, Felipe Mora-Bermúdez |
| Corresponding Authors | |
| Last Authors | Felipe Mora-Bermúdez |
| Journal Name | Current opinion in cell biology (Curr Opin Cell Biol) |
| Volume | 55 |
| Issue | |
| Page Range | 8-16 |
| Open Access | false |
| Print Publication Date | 2018-07-10 |
| Online Publication Date | |
| Abstract | Since their recent development, organoids that emulate human brain tissue have allowed in vitro neural development studies to go beyond the limits of monolayer culture systems, such as neural rosettes. We present here a review of organoid studies that focuses on cortical wall development, starting with a technical comparison between pre-patterning and self-patterning brain organoid protocols. We then follow neocortex development in space and time and list those aspects where organoids have succeeded in emulating in vivo development, as well as those aspects that continue to be pending tasks. Finally, we present a summary of medical and evolutionary insight made possible by organoid technology. |
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| Affiliated With | Huttner, Postdoc first author, Postdocs, Postdoc first male |
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| Publication Status | Published |
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| DOI | 10.1016/j.ceb.2018.06.006 |
| PubMed ID | 30006054 |
| WebOfScience Link | WOS:000451195000003 |
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| Display Publisher Download Only | false |
| Visible On MPI-CBG Website | true |
| PDF Downloadable | true |
| Created By | verhegge |
| Added Date | 2018-07-18 |
| Last Edited By | herbst |
| Last Edited Date | 2021-05-27 18:03:47.284 |
| Library ID | 7174 |
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| Entry Complete | true |
| eDoc Compliant | true |
| Include in Edoc Report | true |
| In Pure | false |
| Ready for eDoc Export | false |
| Author Affiliations Complete | false |
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