Analytical challenges in human plasma lipidomics: A winding path towards the truth

First Authors Olga Vvedenskaya
Authors Olga Vvedenskaya, Yuting Wang, Jacobo Miranda Ackerman, Oskar Knittelfelder, Andrej Shevchenko
Corresponding Authors Andrej Shevchenko
Last Authors Andrej Shevchenko
Journal Name Trends in analytical chemistry (Trends Analyt Chem)
Article Number doi: 10.1016/j.trac.2018.10.013
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Online Publication Date 2018-10-20
Abstract Human plasma lipidome has been extensively studied in many pathophysiological contexts with the hope of identifying biomarkers for early diagnostics and monitoring the progression and treatment of a broad spectrum of diseases. However, despite remarkable progress in lipidomics technologies, the concordance of lipidomics measurements between independent laboratories remains limited and not fulfilling the criteria of common laboratory diagnostics. Here we highlighted a few critical aspects of epidemiological studies of the plasma lipidome, including the selection of study cohorts, collection of plasma samples as well as extraction, identification and quantification of lipids. We argue that reporting the abundances of plasma lipids as molar concentrations is a key turning point during the transition of research lipidomics into a common tool of clinical diagnostics.
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Publication Status Published online
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DOI 10.1016/j.trac.2018.10.013
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Created By shevchenko
Added Date 2018-11-12
Last Edited By thuem
Last Edited Date 2018-12-12 17:05:15.436
Library ID 7251
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