Rab-mediated trafficking in the secondary cells of Drosophila male accessory glands and its role in fecundity.

First Authors Elodie Prince
Authors Elodie Prince, Benjamin Kroeger, Dragan Gligorov, Clive Wilson, Suzanne Eaton, Fran├žois Karch, Marko Brankatschk, Robert K Maeda
Corresponding Authors
Last Authors Robert K Maeda
Journal Name Traffic (Copenhagen, Denmark) (Traffic)
Volume 20
Issue 2
Page Range 137-151
PubMed ID 30426623
WebOfScience Link WOS:000457613100005
Open Access false
Print Publication Date 2019-02-01
Online Publication Date
Abstract The male seminal fluid contains factors that affect female post-mating behavior and physiology. In Drosophila, most of these factors are secreted by the two epithelial cell types that make up the male accessory gland: the main and secondary cells. Although secondary cells represent only ~4% of the cells of the accessory gland, their contribution to the male seminal fluid is essential for sustaining the female post-mating response. To better understand the function of the secondary cells, we investigated their molecular organization, particularly with respect to the intracellular membrane transport machinery. We determined that large vacuole-like structures found in the secondary cells are trafficking hubs labeled by Rab6, 7, 11 and 19. Furthermore, these organelles require Rab6 for their formation and many are essential in the process of creating the long-term postmating behavior of females. In order to better serve the intracellular membrane and protein trafficking communities, we have created a searchable, online, open-access imaging resource to display our complete findings regarding Rab localization in the accessory gland.
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Publication Status Published
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DOI 10.1111/tra.12622
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Created By verhegge
Added Date 2018-12-03
Last Edited By thuem
Last Edited Date 2019-02-22 12:02:45.494
Library ID 7290
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