| First Authors | Nicole Prior |
|---|---|
| Authors | Nicole Prior, Patricia Inacio, Meritxell Huch |
| Corresponding Authors | Meritxell Huch |
| Last Authors | Meritxell Huch |
| Journal Name | Gut (Gut) |
| Volume | 68 |
| Issue | 12 |
| Page Range | 2228-2237 |
| Open Access | true |
| Print Publication Date | 2019-12-01 |
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| Abstract | Organoid cultures have emerged as an alternative in vitro system to recapitulate tissues in a dish. While mouse models and cell lines have furthered our understanding of liver biology and associated diseases, they suffer in replicating key aspects of human liver tissue, in particular its complex architecture and metabolic functions. Liver organoids have now been established for multiple species from induced pluripotent stem cells, embryonic stem cells, hepatoblasts and adult tissue-derived cells. These represent a promising addition to our toolbox to gain a deeper understanding of this complex organ. In this perspective we will review the advances in the liver organoid field, its limitations and potential for biomedical applications. |
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| Affiliated With | Huch |
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| Publication Status | Published |
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| DOI | 10.1136/gutjnl-2019-319256 |
| PubMed ID | 31300517 |
| WebOfScience Link | WOS:000503234500017 |
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| Display Publisher Download Only | false |
| Visible On MPI-CBG Website | true |
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| Created By | thuem |
| Added Date | 2019-10-22 |
| Last Edited By | thuem |
| Last Edited Date | 2020-01-06 16:18:29.036 |
| Library ID | 7527 |
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| Entry Complete | true |
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| Include in Edoc Report | true |
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