Liver organoids: from basic research to therapeutic applications.

First Authors Nicole Prior
Authors Nicole Prior, Patricia Inacio, Meritxell Huch
Corresponding Authors Meritxell Huch
Last Authors Meritxell Huch
Journal Name Gut (Gut)
Volume 68
Issue 12
Page Range 2228-2237
PubMed ID 31300517
WebOfScience Link WOS:000503234500017
Open Access true
Print Publication Date 2019-12-01
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Abstract Organoid cultures have emerged as an alternative in vitro system to recapitulate tissues in a dish. While mouse models and cell lines have furthered our understanding of liver biology and associated diseases, they suffer in replicating key aspects of human liver tissue, in particular its complex architecture and metabolic functions. Liver organoids have now been established for multiple species from induced pluripotent stem cells, embryonic stem cells, hepatoblasts and adult tissue-derived cells. These represent a promising addition to our toolbox to gain a deeper understanding of this complex organ. In this perspective we will review the advances in the liver organoid field, its limitations and potential for biomedical applications.
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Affiliated With Huch
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Publication Status Published
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DOI 10.1136/gutjnl-2019-319256
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Created By thuem
Added Date 2019-10-22
Last Edited By thuem
Last Edited Date 2020-01-06 16:18:29.036
Library ID 7527
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