| First Authors | Tzer Han Tan |
|---|---|
| Authors | Tzer Han Tan, Jifeng Liu, Anne Grapin-Botton |
| Corresponding Authors | Anne Grapin-Botton |
| Last Authors | Anne Grapin-Botton |
| Journal Name | Seminars in cell & developmental biology (Semin Cell Dev Biol) |
| Volume | 141 |
| Issue | |
| Page Range | 23-32 |
| Open Access | false |
| Print Publication Date | 2023-05-30 |
| Online Publication Date | |
| Abstract | The functional relevance of an organoid is dependent on the differentiation, morphology, cell arrangement and biophysical properties, which collectively define the state of an organoid. For an organoid culture, an individual organoid or the cells that compose it, these state variables can be characterised, most easily by transcriptomics and by high-content image analysis. Their states can be compared to their in vivo counterparts. Current evidence suggests that organoids explore a wider state space than organs in vivo due to the lack of niche signalling and the variability of boundary conditions in vitro. Using data-driven state inference and in silico modelling, phase diagrams can be constructed to systematically sort organoids along biochemical or biophysical axes. These phase diagrams allow us to identify control strategies to modulate organoid state. To do so, the biochemical and biophysical environment, as well as the cells that seed organoids, can be manipulated. |
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| Affiliated With | Grapin-Botton, Grill, Postdoc first author, Postdoc first male, Postdocs |
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| Publication Status | Published |
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| DOI | 10.1016/j.semcdb.2022.04.015 |
| PubMed ID | 35466054 |
| WebOfScience Link | WOS:000964440800001 |
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| Display Publisher Download Only | false |
| Visible On MPI-CBG Website | true |
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| Created By | herbst |
| Added Date | 2022-04-27 |
| Last Edited By | thuem |
| Last Edited Date | 2023-04-20 16:17:35.563 |
| Library ID | 8339 |
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| Entry Complete | true |
| eDoc Compliant | true |
| Include in Edoc Report | true |
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| Author Affiliations Complete | false |
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