Organoid Imaging: Seeing Development and Function.

First Authors Rashmiparvathi Keshara
Authors Rashmiparvathi Keshara, Yung Hae Kim, Anne Grapin-Botton
Corresponding Authors Rashmiparvathi Keshara, Yung Hae Kim, Anne Grapin-Botton
Last Authors Anne Grapin-Botton
Journal Name Annual review of cell and developmental biology (Annu Rev Cell Dev Biol)
Volume 38
Issue
Page Range 447-466
Open Access false
Print Publication Date 2022-10-06
Online Publication Date 2022-06-29
Abstract Organoids are miniaturized and simplified versions of an organ produced in vitro from stem or progenitor cells. They are used as a model system consisting of multiple cell types forming an architecture relevant to the organ and carrying out the function of the organ. They are a useful tool to study development, homeostasis, regeneration, and disease. The imaging of organoids has become a pivotal method to visualize and understand their self-organization, symmetry breaking, growth, differentiation, and function. In this review, we discuss imaging methods, how to analyze these images, and challenges in organoid research.
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Affiliated With Grapin-Botton, Predoc first author, Predoc first female
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Publication Status Published
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DOI 10.1146/annurev-cellbio-120320-035146
PubMed ID 35767871
WebOfScience Link WOS:000865583600019
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Created By thuem
Added Date 2022-07-20
Last Edited By thuem
Last Edited Date 2022-11-21 11:17:46.356
Library ID 8389
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Grant ID IRTG 2251
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Funding Organisation DFG