| First Authors |
Juliana G. Roscito
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| Authors |
Juliana G. Roscito, Michael Hiller
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| Corresponding Authors |
Michael Hiller
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| Last Authors |
Michael Hiller
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| Book Volume Title |
Evolution, Origin of Life, Concepts and Methods |
| Series Title |
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| Chapter Number |
6 |
| Publisher |
Springer International Publishing |
| Book Editors |
Pierre Pontarotti
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| ISBN |
978-3-030-30362-4 |
| First Page |
113 |
| Last Page |
134 |
| Open Access |
false |
| Print Publication Date |
2019-10-02 |
| Online Publication Date |
2019-10-02 |
| Abstract |
Understanding which genomic changes are responsible for morphological differences between species is a long-standing question in biology. While evolutionary theory predicts that morphology largely evolves by changing expression of important developmental genes, finding the underlying regulatory mutations is inherently difficult. Here, we discuss how the integration of comparative and functional genomics has provided valuable insights into the regulatory changes involved in morphological changes. By comparing genomes of species exhibiting differences in a morphological trait, comparative genomic methods enable the systematic detection of regulatory elements with divergence in sequence or transcription factor binding sites. To narrow this set of diverged elements down to those that likely contribute to differences in the trait of interest, one can leverage knowledge about gene function to assess which elements are associated with genes known to control the development of this trait. In addition, functional genomics can further prioritize diverged genomic regions based on overlap with experimentally determined regulatory elements that are active in tissues relevant for the trait. Further experiments can then evaluate whether sequence or binding site divergence translates into regulatory differences and affects the development of the trait. Thus, combining comparative and functional genomic approaches provide a widely applicable strategy to reveal regulatory changes contributing to morphological differences, which will enhance our understanding of how nature’s spectacular phenotypic diversity evolved. |
| PDF |
Roscito_2019_7523.pdf
(550.2 kB)
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| Cover Image |
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| Affiliated With |
Hiller, Postdoc first author, Postdocs, CSBD
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| Selected By |
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| Publication Status |
Published |
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| Sfx Link |
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| DOI |
10.1007/978-3-030-30363-1_6 |
| PubMed ID |
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| Display Publisher Download Only |
false |
| Visible On MPI-CBG Website |
true |
| PDF Downloadable |
true |
| Created By |
thuem |
| Added Date |
2019-10-16 |
| Last Edited By |
herbst |
| Last Edited Date |
2021-05-10 18:51:36.334 |
| Library ID |
7523 |
| Document ID |
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| Entry Complete |
true |
| eDoc Compliant |
true |
| Include in Edoc Report |
true |
| In Pure |
false |
| Ready for eDoc Export |
false |
| Author Affiliations Complete |
false |
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